2 problems
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IFN-alpha pathway dependence hypothesis for VV–VSV synergy
Let VV denote vaccinia virus and VSV denote vesicular stomatitis virus. Consider systems in which VV and VSV are combined and compare systems with functional IFN- signaling…
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B18R-mediated enhancement hypothesis for combined VSV and VV therapy
Let VSV denote vesicular stomatitis virus, VV denote vaccinia virus, and B18R denote the VV-encoded protein that suppresses the IFN--mediated antiviral response. Consider t…