MathDB5 problems
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Global stability of the tumour-dominant steady state for positive oxygen consumption
Global-stability conjecture. The steady state remains globally asymptotically stable.
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Parameter dominance hypothesis for VSV and VV infection rates
Let VSV denote vesicular stomatitis virus and VV denote vaccinia virus in the combined-therapy model. Compare changes in the VSV infection rate with comparable changes in the VV in…
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IFN-alpha pathway dependence hypothesis for VV–VSV synergy
Let VV denote vaccinia virus and VSV denote vesicular stomatitis virus. Consider systems in which VV and VSV are combined and compare systems with functional IFN- signaling…
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B18R-mediated enhancement hypothesis for combined VSV and VV therapy
Let VSV denote vesicular stomatitis virus, VV denote vaccinia virus, and B18R denote the VV-encoded protein that suppresses the IFN--mediated antiviral response. Consider t…
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Hypoxia as a design consideration for oncolytic viruses
Hypoxia-design conjecture. Whether the tumour microenvironment is hypoxic should be considered when engineering OVs.