Purely imaginary roots under reverse-reaction removal

Let GG be a reaction network containing the motif

yYy,y\rightleftarrows Y\to y',

where YY appears in no other complex. Let p(h,)p_{(h,\ell)} and p(h,)p'_{(h,\ell')} be the reduced characteristic polynomials of GG and the network obtained by removing YyY\to y, with hR>0nh\in\mathbb{R}^n_{>0}, R>0m\ell\in\mathbb{R}^m_{>0}, and R>0m1\ell'\in\mathbb{R}^{m-1}_{>0}. Purely imaginary-root equivalence conjecture. The polynomial p(h,)p_{(h,\ell)} has purely imaginary roots for some (h,)R>0n×R>0m(h,\ell)\in\mathbb{R}^n_{>0}\times\mathbb{R}^m_{>0} if and only if p(h,)p'_{(h,\ell')} has purely imaginary roots for some (h,)R>0n×R>0m1(h,\ell')\in\mathbb{R}^n_{>0}\times\mathbb{R}^{m-1}_{>0}. Such roots are relevant because they are necessary for the Hopf-bifurcation criterion, while the conjecture itself remains unproved.

Sources & referencesView supporting material

Primary source

Elisenda Feliu and Nidhi Kaihnsa, “Network reduction and absence of Hopf Bifurcations in dual phosphorylation networks with three Intermediates”, arXiv:2405.16179 (2024).

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