Hopf-bifurcation invariance under removing a reverse reaction

Let GG be a reaction network with nn species containing a motif

yYy,y\rightleftarrows Y\to y',

such that the species YY does not appear in any other complex of the network. Let GG' be obtained from GG by removing the backward reaction YyY\to y. Hopf-bifurcation reduction conjecture. The network GG admits a Hopf bifurcation in R>0n\mathbb{R}^n_{>0} if and only if GG' admits a Hopf bifurcation in R>0n\mathbb{R}^n_{>0}. This is a precise form of the proposed reduction principle; the paper provides evidence for it but does not establish it in general.

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Primary source

Elisenda Feliu and Nidhi Kaihnsa, “Network reduction and absence of Hopf Bifurcations in dual phosphorylation networks with three Intermediates”, arXiv:2405.16179 (2024).

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