The coefficient-of-variation bound for fast mRNA–microRNA dynamics
The coefficient-of-variation bound for fast mRNA–microRNA dynamics
Let denote the fast-regime distribution and let denote the corresponding free-mRNA distribution, with their coefficients of variation. Coefficient-of-variation bound. For any and , one has
This would assert that, outside the asymptotic regimes discussed immediately beforehand, binding and production of microRNA do not increase the coefficient of variation relative to free mRNAs. The source presents it as the theoretical result one would like to have; no proof or resolution is supplied here.
Sources & referencesView supporting material
Primary source
Pierre Degond, Maxime Herda and Sepideh Mirrahimi, “A Fokker-Planck approach to the study of robustness in gene expression”, arXiv:2006.14985 (2020).
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