Maximum positive and stable steady states in the full ERK network
Maximum positive and stable steady states in the full ERK network
Consider the full ERK network and the same network with , and let a positive steady state mean a steady state with all relevant concentrations positive; call a steady state positive stable when it is both positive and stable. ERK steady-state conjecture. For each of these two networks, the maximum number of positive steady states is , and the maximum number of positive stable steady states is . This conjecture concerns the sharpness of the bounds in the table and the stability of the steady states; the surrounding discussion establishes multistationarity for the full network but does not resolve these maxima.
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Primary source
Nida Obatake, Anne Shiu, Xiaoxian Tang and Angelica Torres, “Oscillations and bistability in a model of ERK regulation”, arXiv:1903.02617 (2019).
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