Maximum positive and stable steady states in the full ERK network

Consider the full ERK network and the same network with kon=0k_{\mathrm{on}}=0, and let a positive steady state mean a steady state with all relevant concentrations positive; call a steady state positive stable when it is both positive and stable. ERK steady-state conjecture. For each of these two networks, the maximum number of positive steady states is 33, and the maximum number of positive stable steady states is 22. This conjecture concerns the sharpness of the bounds in the table and the stability of the steady states; the surrounding discussion establishes multistationarity for the full network but does not resolve these maxima.

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Primary source

Nida Obatake, Anne Shiu, Xiaoxian Tang and Angelica Torres, “Oscillations and bistability in a model of ERK regulation”, arXiv:1903.02617 (2019).

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