A linear upper bound for the Gaussian Benjamini–Hochberg false discovery rate

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Let GNK\mathcal G^K_{\mathcal N} denote the class of Gaussian-dependent p-value vectors indexed by the hypotheses, and define

fK0,K(α):=sup⁡P∈GNKE[FDαRDα],f_{K_0,K}(\alpha):=\sup_{\mathbf P\in\mathcal G^K_{\mathcal N}}\mathbb E\left[\frac{F_{\mathcal D_\alpha}}{R_{\mathcal D_\alpha}}\right],

where K0K_0 is the number of true null hypotheses. Let

fK(α):=max⁡K0∈KfK0,K(α).f_K(\alpha):=\max_{K_0\in\mathcal K}f_{K_0,K}(\alpha).

Gaussian BH-FDR bound. There exists c⩾1c\geqslant 1 such that

fK(α)⩽cαf_K(\alpha)\leqslant c\alpha

for all α∈(0,1)\alpha\in(0,1) and K∈NK\in\mathbb N. This would give a dimension-free linear bound on the worst-case false discovery rate under Gaussian dependence. The paper states that the value of cc, particularly at small significance levels, is important, but whether such a universal constant exists remains open.

References

Primary source

Ziyu Chi, Aaditya Ramdas and Ruodu Wang, “Multiple testing under negative dependence”, arXiv:2212.09706 (2024).

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