A linear upper bound for the Gaussian Simes-test error probability

Let GK\mathcal G^K denote the class of Gaussian-dependent vectors of KK p-values, and let SK(P)S_K(\mathbf P) be the Simes p-value for P\mathbf P. Define

sK(α):=supPGKP(SK(P)α).s_K(\alpha):=\sup_{\mathbf P\in\mathcal G^K}\mathbb P\bigl(S_K(\mathbf P)\leqslant\alpha\bigr).

Gaussian Simes bound. There exists c1c\geqslant 1 such that

sK(α)cαs_K(\alpha)\leqslant c\alpha

for all α(0,1)\alpha\in(0,1) and KNK\in\mathbb N. If true, determining the smallest possible cc, especially for practically relevant small values of α\alpha, is important. The paper notes that the currently available general bound grows with KK, so whether a universal constant exists remains open.

Sources & referencesView supporting material

Primary source

Ziyu Chi, Aaditya Ramdas and Ruodu Wang, “Multiple testing under negative dependence”, arXiv:2212.09706 (2024).

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