A linear upper bound for the Gaussian Simes-test error probability

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Let GK\mathcal G^K denote the class of Gaussian-dependent vectors of KK p-values, and let SK(P)S_K(\mathbf P) be the Simes p-value for P\mathbf P. Define

sK(α):=sup⁡P∈GKP(SK(P)⩽α).s_K(\alpha):=\sup_{\mathbf P\in\mathcal G^K}\mathbb P\bigl(S_K(\mathbf P)\leqslant\alpha\bigr).

Gaussian Simes bound. There exists c⩾1c\geqslant 1 such that

sK(α)⩽cαs_K(\alpha)\leqslant c\alpha

for all α∈(0,1)\alpha\in(0,1) and K∈NK\in\mathbb N. If true, determining the smallest possible cc, especially for practically relevant small values of α\alpha, is important. The paper notes that the currently available general bound grows with KK, so whether a universal constant exists remains open.

References

Primary source

Ziyu Chi, Aaditya Ramdas and Ruodu Wang, “Multiple testing under negative dependence”, arXiv:2212.09706 (2024).

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