Degree-three invariant recovery in the cryo-EM model

Consider the cryo-EM model

yi=P(gif)+εi,y_i=P(g_i\boldsymbol{\cdot} f)+\varepsilon_i,

where PP is the tomographic projection and RR denotes the number of spherical shells.

Cryo-EM sample-complexity conjecture. If R3R\geq 3 is large enough, then the minimal number of observations required for accurate recovery of the O(n)\operatorname{O}(n) orbit of ff, regardless of any specific algorithm, satisfies

m/σ6.m/\sigma^6\to\infty.

This conjecture concerns recovery from degree-three invariants in cryo-EM. It was recently proved, so the conjectural statement is no longer open.

Sources & referencesView supporting material

Primary source

Tamir Bendory, Dan Edidin, Josh Katz and Shay Kreymer, “Orbit recovery for spherical functions”, arXiv:2508.02674 (2026).

Additional references

2 papers in this index state this conjecture (2017–2025). The statement above is taken from the most recent of them; the others are arXiv:1712.10163.

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