Unidentifiability conjecture for the mammillary model with input 2 and output 3

Let n≥5n\geq 5. Let M=(G,In,Out,Leak)\mathcal M=(G,\textit{In},\textit{Out},\textit{Leak}) be an nn-compartment mammillary model with In={2}\textit{In}=\{2\}, Out={3}\textit{Out}=\{3\}, and Leak=∅\textit{Leak}=\varnothing. A parameter is unidentifiable if it cannot be recovered from the coefficient map. Unidentifiability conjecture. The parameters

k12,k21,k13,k31,k41,…,kn1k_{12},\quad k_{21},\quad k_{13},\quad k_{31},\quad k_{41},\dots,k_{n1}

are unidentifiable. This conjecture completes the identifiability classification suggested by Proposition 2.3; the parameters k14,…,k1nk_{14},\dots,k_{1n} are generically locally identifiable, while the stated unidentifiability of the remaining parameters is not established here.

References

Primary source

Katherine Clemens, Jonathan Martinez, Anne Shiu, Michaela Thompson and Benjamin Warren, “Parameter Identifiability of Linear-Compartmental Mammillary Models”, arXiv:2506.21889 (2025).

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