Unidentifiability conjecture for the mammillary model with input 2 and output 3

From papers

Let n5n\geq 5. Let M=(G,In,Out,Leak)\mathcal M=(G,\textit{In},\textit{Out},\textit{Leak}) be an nn-compartment mammillary model with In={2}\textit{In}=\{2\}, Out={3}\textit{Out}=\{3\}, and Leak=\textit{Leak}=\varnothing. A parameter is unidentifiable if it cannot be recovered from the coefficient map. Unidentifiability conjecture. The parameters

k12,k21,k13,k31,k41,,kn1k_{12},\quad k_{21},\quad k_{13},\quad k_{31},\quad k_{41},\dots,k_{n1}

are unidentifiable. This conjecture completes the identifiability classification suggested by Proposition 2.3; the parameters k14,,k1nk_{14},\dots,k_{1n} are generically locally identifiable, while the stated unidentifiability of the remaining parameters is not established here.

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Sources & referencesView supporting material

Primary source

Katherine Clemens, Jonathan Martinez, Anne Shiu, Michaela Thompson and Benjamin Warren, “Parameter Identifiability of Linear-Compartmental Mammillary Models”, arXiv:2506.21889 (2025).

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