Additional hyperplanes conjecture for directed-cycle model singular loci

Let n3n \geq 3, and let M=(G,In,Out,Leak)\mathcal{M} = (G, \textit{In}, \textit{Out}, \textit{Leak}) be an nn-compartment directed-cycle model with In={1}\textit{In}=\{1\} and Out={p}\textit{Out}=\{p\}, where 1pn1 \leq p \leq n. Assume that M\mathcal{M} is generically locally identifiable, equivalently, that it is leak-interlacing. For a([p1]Leak)a \in ([p-1] \smallsetminus \textit{Leak}) and (Leak[p])\ell \in (\textit{Leak} \cap [p]), define the corresponding rate parameters ka+1,ak_{a+1,a}, k+1,k_{\ell+1,\ell}, and leak parameter k0k_{0\ell}. Additional hyperplanes conjecture. For every such aa and \ell, the singular locus of M\mathcal{M} contains the hyperplane

{k+1,+k0=ka+1,a}.\{k_{\ell+1,\ell}+k_{0\ell}=k_{a+1,a}\}.

This conjecture predicts further components of the singular locus beyond those established for the case In=Out={1}\textit{In}=\textit{Out}=\{1\}. Proving it would extend the known description of singular loci for generically locally identifiable, or leak-interlacing, directed-cycle compartment models.

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Primary source

Saber Ahmed, Natasha Crepeau, Paul R. Dessauer, Alexis Edozie, Odalys Garcia-Lopez, Tanisha Grimsley, Jordy Lopez Garcia, Viridiana Neri and Anne Shiu, “Identifiability of directed-cycle and catenary linear compartment models”, arXiv:2412.05283 (2025).

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